Study to find pain killers with minimum side effects is one of the researchers interest. In prior study, analgesic effect of Ferula szowitsiana up to dose of 200mg/kg was seen. In this investigation antinociceptive effect of Ferula szowitsiana was compared between the intrapritoneal (i.p.) doses of 200mg/kg and 400‌mg/kg and then compared with the same equivalent concentration for dose of 400‌mg/kg but at the intrathechal (i.t.) administration.‌ Hydroalcoholic extract of Ferula szowitsiana was prepared and dissolved in saline, tween 80 and ethanol (8/1/1 respectively). Male wistar rats (200-250gr) were placed in 6 groups (n=7): control, i.p. solvent, i.t. solvent, i.p. 200mg/kg, i.p. 400mg/kg and i.t. equivalent of 400mg/kg. To assess pain sensation, formalin test is used. Analgesic effect of 400mg/kg extract dose was greater than the dose of 200mg/kg at the i.p. administration (P<0.05). Also there was no difference between analgesic effects of extract in dose of 400mg/kg, i.p. and its i.t. equivalent concentration. ‌Results shown that Ferula szowitsiana extract, dose dependently had analgesic effect in systemic administration. No difference between analgesic effects of systemic and central administration implies that the analgesia is governed by extract centrally; this assumption is needed to study more.

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