In the past two decades, tissue engineering has shown a great potential in regeneration of various tissues and organs. Three important components in this technology include scaffolds, cells and growth factors. Tissue engineering can be performed via various routs including transplantation of cells, delivery of inducing substances like growth factors into the tissues and also growing cells on scaffolds before their placement into the organism.Scaffolds used in tissue engineering can be natural or synthetic three dimensional biomaterials with specific po rosity, which should be biocompatible, biodegradable and suitable for induction of cell growth, survival, proliferation, migration and differentiation. Natural scaffolds are advantageous in that they are biocompatible, contain different materials and have suitable biological properties. We have prepared natural scaffolds from different tissues and organs including bone, cartilage, skin, pancreas, esophagus, kidney, lung, tendon and amniotic membrane. Here we show that natural scaffolds can be prepared with various methods and they provide a suitable matrix for induction of cellular migration and differentiation in vitro . These scaffolds can also be applied in the clinic for replacement of injured tissues

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