Title : ( Preparation of the human bone 3D matrix and investigating interactions between mouse adherent bone marrow cells and this matrix. )
Authors: elham abedin , Roya Lari , Nasser Mahdavi SHahri ,
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Abstract
Introduction: Isolated and decellularized extracellular matrix of mammalian tissues can be used as a scaffold for repair and reconstruction of bone defects. Materials & Methods: In this study, extracellular matrix of human trabecular and cancellous bone were used as a three-dimensional scaffold to investigate the migration and function of mouse bone marrow -adherent cells . The cells of the extracellular matrix have been removed and bone marrow adherent cells were cultured on decellularized matrix for different time periods. Results: Our results indicated that the cells were adhered, migrated and probably differentiated in the three-dimensional bone matrix. Discussion: Therefore scaffold is a good model to study cell polarity and movement is in vitro conditions and has a potentiality to be use for repair and renewal of bone defects.
Keywords
, decellularization, extracellular matrix, three-dimensional scaffold, bone marrow -adherent cells
@inproceedings{paperid:1049736,
author = {Abedin, Elham and Lari, Roya and Mahdavi SHahri, Nasser},
title = {Preparation of the human bone 3D matrix and investigating interactions between mouse adherent bone marrow cells and this matrix.},
booktitle = {2nd Basic and Clinical Neuroscience Congress 2013},
year = {2013},
location = {تهران, IRAN},
keywords = {decellularization; extracellular matrix; three-dimensional scaffold; bone marrow -adherent cells},
}
%0 Conference Proceedings
%T Preparation of the human bone 3D matrix and investigating interactions between mouse adherent bone marrow cells and this matrix.
%A Abedin, Elham
%A Lari, Roya
%A Mahdavi SHahri, Nasser
%J 2nd Basic and Clinical Neuroscience Congress 2013
%D 2013
