Asian Pacific Journal of Cancer Prevention, ( ISI ), Volume (14), No (6), Year (2013-3) , Pages (3403-3409)

Title : ( Hereditary Genes and SNPs Associated with Breast Cancer )

Authors: Mohammad Mahdi Kooshyar , Mohammadreza Nassiri , khadijeh nasiri ,

Citation: BibTeX | EndNote

Abstract

Breast cancer is the most common cancer among women affecting up to one third of tehm during their lifespans.Increased expression of some genes due to polymorphisms increases the risk of breast cancer incidence. Since mutations that are recognized to increase breast cancer risk within families are quite rare, identification of these SNPs is very important. The most important loci which include mutations are; BRCA1, BRCA2, PTEN, ATM, TP53, CHEK2, PPM1D, CDH1, MLH1, MRE11, MSH2, MSH6, MUTYH, NBN, PMS1, PMS2, BRIP1, RAD50,RAD51C, STK11 and BARD1. Presence of SNPs in these genes increases the risk of breast cancer and associated diagnostic markers are among the most reliable for assessing prognosis of breast cancer. In this article we reviewed the hereditary genes of breast cancer and SNPs associated with increasing the risk of breast cancer that were recently were reported from candidate gene, meta-analysis and GWAS studies. SNPs of genes associated with breast cancer can be used as a potential tool for improving cancer diagnosis and treatment planning.

Keywords

, Breast cancer, hereditary genes, SNPs
برای دانلود از شناسه و رمز عبور پرتال پویا استفاده کنید.

@article{paperid:1050038,
author = {Mohammad Mahdi Kooshyar and Nassiri, Mohammadreza and Nasiri, Khadijeh},
title = {Hereditary Genes and SNPs Associated with Breast Cancer},
journal = {Asian Pacific Journal of Cancer Prevention},
year = {2013},
volume = {14},
number = {6},
month = {March},
issn = {1513-7368},
pages = {3403--3409},
numpages = {6},
keywords = {Breast cancer; hereditary genes; SNPs},
}

[Download]

%0 Journal Article
%T Hereditary Genes and SNPs Associated with Breast Cancer
%A Mohammad Mahdi Kooshyar
%A Nassiri, Mohammadreza
%A Nasiri, Khadijeh
%J Asian Pacific Journal of Cancer Prevention
%@ 1513-7368
%D 2013

[Download]