Title : ( Strategies to improve homing of mesenchymal stem cells for greater efficacy in stem cell therapy. )
Authors: Hojjat Naderi-Meshkin , Ahmad Reza Bahrami , Hamid Reza Bidkhori , Mahdi Mirahmadi , Naghmeh Ahmadiankia ,
Full TextAbstract
Stem/progenitor cell-based therapeutic approach in clinical practice has been an elusive dream in medical sciences, and improvement of stem cell homing is one of major challenges in cell therapy programs. Stem/progenitor cells have a homing response to injured tissues/organs, mediated by interactions of chemokine receptors expressed on the cells and chemokines secreted by the injured tissue. For improvement of directed homing of the cells, many techniques have been developed either to engineer stem/progenitor cells with higher amount of chemokine receptors (stem cell-based strategies) or to modulate the target tissues to release higher level of the corresponding chemokines (target tissue-based strategies). This review discusses both of these strategies involved in the improvement of stem cell homing focusing on mesenchymal stem cells as most frequent studied model in cellular therapies.
Keywords
chemokine receptors; homing; mesenchymal stem cells; preconditioning; therapy
@article{paperid:1053019,
author = {Hojjat Naderi-Meshkin and Bahrami, Ahmad Reza and Hamid Reza Bidkhori and Mahdi Mirahmadi and Naghmeh Ahmadiankia},
title = {Strategies to improve homing of mesenchymal stem cells for greater efficacy in stem cell therapy.},
journal = {Cell Biology International},
year = {2015},
volume = {39},
number = {1},
month = {December},
issn = {1065-6995},
pages = {23--34},
numpages = {11},
keywords = {chemokine receptors; homing; mesenchymal stem cells; preconditioning; therapy},
}
%0 Journal Article
%T Strategies to improve homing of mesenchymal stem cells for greater efficacy in stem cell therapy.
%A Hojjat Naderi-Meshkin
%A Bahrami, Ahmad Reza
%A Hamid Reza Bidkhori
%A Mahdi Mirahmadi
%A Naghmeh Ahmadiankia
%J Cell Biology International
%@ 1065-6995
%D 2015
