Heterocyclic Communications, ( ISI ), Volume (22), No (1), Year (2016-1) , Pages (49-53)

Title : ( Microwave-assisted synthesis and antibacterial evaluation of new derivatives of 1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one )

Authors: , Ali Shiri , Mehdi Bakavoli , Seyed Mohammad Seyedi , Masoumeh Bahreini , Fatemeh Oroojalian ,
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Abstract

The synthesis of new derivatives of 1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one are reported through the treatment of ethyl 4-hydroxy-2-amino-pyrimidine-5-carboxylate 2a-c and few hydrazine derivatives under classical heating and microwave-induced synthesis. The antibacterial activities as MIC and MBC of these new synthesized compounds were evaluated comparable to chloramphenicol and streptomycin as reference drugs.

Keywords

, Pyrazolo[3, 4-d]pyrimidin-3-one; Antibacterial activity; Microwave-induced synthesis.