Background and Aim : Micronutrients are necessary for human bodies and involved in different reaction and biochemistry process. Reduction or increase in the amount of micronutrients can disrupt normal function of the body. Different micronutrients such as Mg2, Mn2, Zn2 and Cu2 affect the central nervous system and may be effective in pain and inflammation. Our previous study has shown that effective dose of cucl2 which caused analgesia subsequent to chemical pain induced by formalin in rat paw is 10 mg/kg dose. In this study the effect of naloxone on cucl2 analgesic effects was assessed to find any relenship between cucl2 analgesia and opioid system was assed....

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