Synlett, ( ISI ), Volume (27), Year (2016-4) , Pages (1669-1673)

Title : ( An unexpected diastereoselective synthesis of novel substituted pyridines via one-pot, four-component reaction )

Authors: mahdie zangouei , Abbas Ali Esmaeili , Joel T. Mague ,

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An efficient diastereoselective approach for the preparation of novel substituted pyridines has been developed through a one-pot, four-component reaction of easily available aromatic aldehydes, malononitrile, and 6,8-dimethyl-2-hydroxy-4H-pyrimido[1,2-a]pyrimidine-4-one, in appropriate alcohols at reflux in the presence of DIPEA (diisopropyl ethyl amine) as organic base catalyst. Unexpected products were obtained in high to excellent yields using a simple workup procedure. The product synthesized showed high diastereoselectivity in which its stereochemistry was confirmed by X-ray diffraction analysis.

Keywords

, Multicomponent reaction, Diastereoselective synthesis, 6, 8-dimethyl-2-hydroxy-4H-pyrimido[1, 2-a]pyrimidine-4-one, Malononitrile,
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@article{paperid:1056872,
author = {Zangouei, Mahdie and Esmaeili, Abbas Ali and Joel T. Mague},
title = {An unexpected diastereoselective synthesis of novel substituted pyridines via one-pot, four-component reaction},
journal = {Synlett},
year = {2016},
volume = {27},
month = {April},
issn = {0936-5214},
pages = {1669--1673},
numpages = {4},
keywords = {Multicomponent reaction; Diastereoselective synthesis; 6;8-dimethyl-2-hydroxy-4H-pyrimido[1;2-a]pyrimidine-4-one; Malononitrile; 2-oxo-4-phenyl-1;2;3;4-tetrahydropyridine.},
}

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%0 Journal Article
%T An unexpected diastereoselective synthesis of novel substituted pyridines via one-pot, four-component reaction
%A Zangouei, Mahdie
%A Esmaeili, Abbas Ali
%A Joel T. Mague
%J Synlett
%@ 0936-5214
%D 2016

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