Achillea eriophora D. C. (Asteraceae) is an endemic plant species of Iran. This species, with the local name of Sarzardu, is widely used as a folk remedy treatment of many ailments. Traditionally, in Iran as well as many European countries it was prevalented the usage of Achillea tea for remedy of fever, cold, menstrual cramps, kidney problems and gastrointestinal disturbances. Also this plant has been used as salve for relief of wound and skin inflammation. Several studies have indicated interesting biological activities, including antimicrobial, antioxidant,anti-inflammatory, antispasmodic, antidiabetic, anticancer, antiulcer effects (Nemeth et al., 2008) and wound healing activity (Hemmati et al., 2002; Nirmala et al., 2011; Pirbalouti et al., 2010) for different species of genus Achillea. Some researches have attributed antimicrobial, antioxidant (Candan et al., 2003; Skočibušić et al., 2004) and anti-inflammatory (Al-Hindawi et al., 1989) properties of Achillea species to the substantial amounts of flavonoids and terpenoids present in their extracts or essential oils. Wound healing is a dynamic, and interactive process involving soluble mediators, blood cells, extracellular matrix, and mesenchymal cells. It involves four different phases of hemostasis, inflammation, granulation, and tissue remodeling (or maturation), that overlap in time. Fibroblast migration to and proliferation within the wounded area are prerequisites for wound granulation. Fibroblasts then participate in construction of the scar tissue and its remodeling (Singer et al., 1999). The aim of the present study was to investigate the effect of the leaf methanolic extract of Achillea eriophora on the proliferation of human fibroblast and also their migrative capacity in a cultured monolayer, serving as in vitro wound model.

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