Background: Spirulina is a microscopic and filamentous cyanobacterium that contains essential amino acids, essential fatty acids, vitamins, minerals and anti-oxidative components. We aimed to investigate whether Spirulina platensis protects the heart against the oxidative imbalance promoted by type 2 diabetes. Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion and insulin action or both. Oxidative stress plays a central role in diabetic tissue damage. The chronic hyperglycemia is associated with long-term damage, dysfunction, and failure of normal functioning of various organs, especially the eyes, kidneys, nerves, heart, and blood vessels. Material method: : For this purpose we compared heart homogenates obtained from untreated diabetic rats versus diabetic rats treated with Spirulina during a period of 2 months. 28 male Wistar rats (Weight: 250 ± 20 g) were divided into four groups (n=7), 1: control, 2: Spirulina, 3: Diabetes mellitus (STZ: 45 mg.kg-1 BW, IP) and 4: Diabetes mellitus + Spirulina. Spirulina concentrate was administered orally (14 mg.kg-1 BW/ day). At the end of the study (60 days) rats were euthanized thereafter liver specimen were collected and homogenized for evaluation of biochemical parameters such as Malondialdehyde (MDA), FRAP and thiol group. Result: The MDA levels and FRAP had significant differences in both untreated and treated diabetic rats when compared with control group (p<0.05). Conclusion: These results indicate that Spirulina platensis could not be an effective cardioprotective agent in diabetic rats because it cannot protect heart against diabetes-associated oxidative stress. Diabetes mellitus, Spirulina, Oxidative stress, MDA, FRAP, Heart

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