Background: Oxidative stress plays a central role in diabetic tissue damage and the present investigation was performed to evaluate the antioxidant activities of Spirulina platensis in liver of streptozotocin induced diabetic rats. Antihyperglycemic and antioxidant activities have been recorded with numerous plants, many of which are used as traditional herbal treatments of diabetes. Spirulina is a microscopic single cell alga which grows in fresh water and contains various antioxidants, especially phycocyanin. Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion and insulin action or both. The chronic hyperglycemia is associated with longterm damage, dysfunction, and failure of normal functioning of various organs, especially the eyes, kidneys, nerves, heart, and blood vessels. Material method: 28 male Wistar rats (Weight: 250 ± 20 g) were divided into four groups (n=7), 1: control, 2: Spirulina, 3: Diabetes mellitus (STZ: 45 mg.kg-1 BW, IP) and 4: Diabetes mellitus + Spirulina. Spirulina concentrate was administered orally (14 mg.kg-1 BW/ day). At the end of the study (60 days) rats were euthanized thereafter liver specimen were collected and homogenized for evaluation of biochemical parameters such as Malondialdehyde (MDA), FRAP and thiol group. Result: FRAP values thiol group in liver specimen significantly increased in groups received Spirulina as compared to diabetic rats (p<0.05). Conclusion: The liver MDA concentration was significantly decreased following Spirulina supplementation in groups received Spirulina as compared to the diabetic rats (p<0.05). Our findings showed that Spirulina markedly reduced associated oxidative complications in STZ-induced diabetic rats.

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