This study was conducted to investigate the effect of different levels of dietary nanomicelles curcumin (NC) on serum biochemical parameters and immune system of laying hens. For this purpose, a total of 160 laying hens of Hy-Line strain were used in a completely randomized design, including 4 treatments with 4 replicates of 10 hens each. Birds were 60 weeks old and experiment period was 8 weeks. Dietary treatments were a basal diet without nano curcumin (control) and diets containing 400, 800 and 1200 mg nanomicelle curcumin per kg of the diet. The Evaluation of serum biochemical parameters was conducted in week 4 and 8. Serum immunology factors were also evaluated after SRBC injection (in week six) and blood sampling in seventh and eighth weeks of trial period which improved immune system (P<0.05). By investigating serum biochemical parameters in the middle of experiment it was revealed that ALT and AST concentration significantly decreased (P<0.05) under the effect of low-dose NC. Concentrate of cholesterol, LDL and HDL: LDL ratio were affected by NC consuming levels (P<0.05) at the end of experiment. Level of 400 mg of NC showed the best immune response compared to those of control and levels of 800 and 1200 mg. The results of this study generally showed that using different levels of NC specifically in the low level (400 mg) reduced lipids profile of serum and improved hepatic enzyme activities and immunity system in the final weeks of the experiment.

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