Introduction: Early positioning in altitude increases hypoxia and Oxygen pressure reduction, hypoxia level inducing factor and vascular endothelial growth factor in skeletal and cardiac muscle and causes adaptation in athletes as function improvement and their better record in sea level. This study purpose is comparing effects of ascent to three thousand altitude with three different intensity onHIF-1a, Vo2max, VEGF in amateur male and female mountaineers. Methodology: This semi-experimental research was done on 60 amateur male and female mountaineers with 25to 26 yeas old mean, 57 to 72 KG weight, 22 to 25 KG/m2BMI and 40 to 45 mL/KG.min Vo2max.Subjects ascended to 3 thousand altitude Salook mountaintop with three different intensity of maximum heart rate (60-70-80), 12/45±5/86% gradient, 9/74±4/54 °C and 36/91±5/10% humidity and 761±39/04 mmHg barometric pressure in three female experimental groups (n=3*10) and three male experimental groups (n=3*10). Bloodletting and statistical data was measured in three stages, before ascending, immediately after ascending to altitude, 2 hours after residence in three thousand altitude. One way ANOVA was used along repeated measurements with significance level (0/05) for data analysis( table 1 and 2 and 3). Results: Study results showed changes in mountaineer’s weight, BMI, fat percentage and Vo2 max. HIF-1a, Vo2max, VEGF was observed in three females groups and three males groups. Conclusion: According to recent project results, it seems that acceding to three thousand altitude with definite intensity caused HIF-1a, Vo2max, VEGF increasing in addition to energy economic consumption and at last athletes function improvement.

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