Introduction:D-dimer is the final product of Fibrinolysin that is measured to ensure we have no Increasing in blood clots production. The aim of this study was to determine the effect of eight weeks of interval endurance-resistsnce concurrent endurance-resistance on the fluctuation of D-dimer and lipid profile in overweight women. Materials and Methods: In this quasi-experimental study, 36 obese women aged 20 to 30 years Unbounded available sampling and targeted randomly divided into three groups with 12 people for each group: two exercise groups and one control group. Training program consist of Three sessions a week on non-consecutive for eight-week.for introducing within group and between groups significant, one way ANOVA has been taken and results in the significant level of P (≤0 / 05) were tested. Results: The experimental values of D-dimer in both experimental groups compared to the control group showed no significant changes, TG levels in both exercise groups compared to the control group have shown significantly reducing, changing in amounts of LDL and HDL variable in groups was not significant. Conclusion: It seems there is no significant difference between these two protocols and factors such as the intensity / greater volume and better diet can express effects.

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