Title : ( Effects of 8 Weeks of Resistance Training and IGF -1 Injection on Biochemical Markers of Cancer and Colorectal Structures in Rats )
Authors: babisan askari galugahi , Nahid Bijeh , Amir Rashidlamir ,
Full TextAbstract
Background and Objectives:We studied the effects of eight weeks of resistance training and IGF -1 injection on serum level of IGF1, IGFBP 3 and IGF-1/IGFBP-3 ratio in Wistar rats. Methods: We randomly divided 28 male Wistar rats into four groups of saline injected control (C), resistance training+saline injection (RS), resistance training+IGF-1 injection (RI) and IGF-1 injection (II). Resistance training protocol consisted of climbing a lad der (three days/week with 5 reps/3 sets) while carrying a weight suspended from the tail for eight weeks. IGF 1 and saline (1.5 μg/kg/day) were injected before and after exercise sessions. Serum IGF 1, IGFBP 3 and IGF 1/IGFBP 3 ratio and morphology of colorectal tissue were evaluated. Results:Serum IGF1 level and IGF1/IGFBP3 ratio decreased in the RS group compared to the other groups (P< 0.05). Rats in the RS group had higher IGFBP3 level than those in the II and RI groups (P< 0.05). IGF1injection had no effect on morphology of colorectal tissue. Conclusion: The resistance training reduces IGF-1 and increases IGFBP3 levels, which might represent a link between resistance training and lower risk of colorectal cancer.
Keywords
, Exercise, Colorectal Neoplasms, Insulin-Like Growth Factor-1, Insulin-Like Growth Factor Binding protein-3
@article{paperid:1067169,
author = {Askari Galugahi, Babisan and Bijeh, Nahid and Rashidlamir, Amir},
title = {Effects of 8 Weeks of Resistance Training and IGF -1 Injection on Biochemical Markers of Cancer and Colorectal Structures in Rats},
journal = {Medical Laboratory Journal},
year = {2018},
volume = {11},
number = {6},
month = {February},
issn = {1735-9007},
pages = {1--7},
numpages = {6},
keywords = {Exercise; Colorectal Neoplasms; Insulin-Like Growth Factor-1; Insulin-Like Growth Factor Binding protein-3},
}
%0 Journal Article
%T Effects of 8 Weeks of Resistance Training and IGF -1 Injection on Biochemical Markers of Cancer and Colorectal Structures in Rats
%A Askari Galugahi, Babisan
%A Bijeh, Nahid
%A Rashidlamir, Amir
%J Medical Laboratory Journal
%@ 1735-9007
%D 2018
