Pharmacogenomics, Volume (19), No (6), Year (2018-4) , Pages (539-546)

Title : ( A genetic polymorphism in the CYP1B1 gene in patients with squamous cell carcinoma of the esophagus: an Iranian Mashhad cohort study recruited over 10 years )

Authors: , , , , , , , Mohammadreza Nassiri , , , , , , , , ,

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Abstract

Aim: Esophageal cancer is the eighth most common cancer globally and the seventh most common cause of cancer-related deaths in men. Recent studies have shown that CYP450, family 1, subfamily B, polypeptide 1, which plays a role in the metabolism of xenobiotics, is associated with several cancers. Therefore, in the present study we investigated the association between a genetic variant, CYP1B1-rs1056836 gene, with the clinical characteristics of patients with squamous cell carcinoma of the esophagus (ESCC). Method: In this study, 117 patients with ESCC and 208 healthy controls were recruited. DNA was extracted and genotyped using real-time PCR-based TaqMan. Kaplan–Meier curves were utilized to assess overall and progression-free survival. To evaluate the relationship between clinicopathological data, genotypic frequencies, disease prognosis and survival, Pearson’s χ2 and t-test were used. Logistic regression was utilized to assess the association between the risk of ESCC and genotypes. Results: The genotypic frequency for GG, GC and CC were 58.6, 29.8 and 11.5%, respectively, in the healthy subjects and 51.8, 36.14 and 12% in the ESCC group. An association between the GG genotype and stage of ESCC was found. Also, statistically significant results were not found for this variation and risk of ESCC. Conclusion: Our findings suggest a relationship between the CYP1B1-rs1056836 genetic polymorphism and clinical features of ESCC, supporting further studies in larger populations in different ethnic groups, taking into account potentially important environmental factors such as diet.

Keywords

, cytochrome p450 , esophagus squamous cell carcinoma
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@article{paperid:1068078,
author = { and and and and and and and Nassiri, Mohammadreza and and and and and and and and },
title = {A genetic polymorphism in the CYP1B1 gene in patients with squamous cell carcinoma of the esophagus: an Iranian Mashhad cohort study recruited over 10 years},
journal = {Pharmacogenomics},
year = {2018},
volume = {19},
number = {6},
month = {April},
issn = {1462-2416},
pages = {539--546},
numpages = {7},
keywords = {cytochrome p450 ; esophagus squamous cell carcinoma},
}

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%0 Journal Article
%T A genetic polymorphism in the CYP1B1 gene in patients with squamous cell carcinoma of the esophagus: an Iranian Mashhad cohort study recruited over 10 years
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%A Nassiri, Mohammadreza
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%J Pharmacogenomics
%@ 1462-2416
%D 2018

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