Background and purpose: the important factors in the development of chronic diseases are obesity and overweight. The purpose of this study was to investigate the effect of eight-week aerobic training on interleukin 6, insulin resistance and glucose among overweight young girls. Methods: Twenty-one girls with an age range of 20-30 years were selected voluntarily and randomly divided into experimental (n = 11) and control (n = 10) groups. The aerobic exercise program lasted for 8 weeks, with a frequency of 3 sessions per week, with training sessions starting from 30 minutes in the first session and 50 minutes in the final session, and the intensity of 60-70% of the heart rate reserve. The blood sample was taken before beginning the main study program. The dependent t-test and the Kolmogorov–Smirnov test was used to compare the pre-test and post-test information between the groups. Findings: In this study, 8 weeks of aerobic exercise resulted in a significant decrease in the weight of the subjects (P<0.05) also, changes in the other subjects (body mass index, body fat percentage, waist to hip ratio) were not significant (P >0.05). Conclusion: The results of this study showed that eight-week aerobic exercise program could be beneficial for weight loss, but it did not affect glucose concentration, insulin resistance, interleukin 6 serum, fat percentage of blood, waist to hip ratio and BMI.

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