Title : ( Synthesis of 2-substituted-4-methyl-5,13- dihydropyrimido[4',5':5,6][1,4]thiazepino[2,3- b]quinoxaline as a new heterocyclic system )
Authors: marzieh akbarzadeh , Mehdi Bakavoli , Hossein Eshghi , Ali Shiri , Hamid Azizollahi , Joel T. Mague ,
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Abstract
2-Substituted-4-methyl-5,13-dihydropyrimido[4',5':5,6][1,4]thiazepino[2,3-b]quinoxalines (7a-g), derivatives of a new heterocyclic system were synthesized through cyclocondensation of 2,4-dichloro-5-(chloromethyl)-6-methylpyrimidine (3) with 3-aminoquinoxaline-2-thiol (4) and subsequent substitution by various secondary amines. Regioselective heterocyclization was confirmed by X-ray crystallographic analysis for 4-methyl-2-(pyrrolidin-1-yl)-5,13-dihydropyrimido[4',5':5,6] [1,4]thiazepino[2,3-b]quinoxaline (7a).
Keywords
, 1, 4-thiazepine, pyrimidothiazepine, quinoxaline-2, 3-dithiol, intramolecular SNAr reaction
@article{paperid:1069728,
author = {Akbarzadeh, Marzieh and Bakavoli, Mehdi and Eshghi, Hossein and Shiri, Ali and Azizollahi, Hamid and Joel T. Mague},
title = {Synthesis of 2-substituted-4-methyl-5,13- dihydropyrimido[4',5':5,6][1,4]thiazepino[2,3- b]quinoxaline as a new heterocyclic system},
journal = {Phosphorus, Sulfur, and Silicon and the Related Elements},
year = {2018},
volume = {193},
number = {9},
month = {September},
issn = {1042-6507},
pages = {545--551},
numpages = {6},
keywords = {1;4-thiazepine; pyrimidothiazepine; quinoxaline-2;3-dithiol; intramolecular SNAr reaction},
}
%0 Journal Article
%T Synthesis of 2-substituted-4-methyl-5,13- dihydropyrimido[4',5':5,6][1,4]thiazepino[2,3- b]quinoxaline as a new heterocyclic system
%A Akbarzadeh, Marzieh
%A Bakavoli, Mehdi
%A Eshghi, Hossein
%A Shiri, Ali
%A Azizollahi, Hamid
%A Joel T. Mague
%J Phosphorus, Sulfur, and Silicon and the Related Elements
%@ 1042-6507
%D 2018
