International Journal of Biological Macromolecules, ( ISI ), Year (2018-8)

Title : ( Targeted delivery of adenosine 5′-triphosphate using chitosan-coated mesoporous hydroxyapatite: A theranostic pH-sensitive nanoplatform with enhanced anti-cancer effect )

Authors: mohadese sadat feiz , Azadeh Meshkini ,

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Abstract

In this Study, a pH-sensitive nanoplatform made up of chitosan (Cs) and mesoporous hydroxyapatite (HAP) was synthesized and employed for delivering of adenosine 5′-triphosphate (ATP). The fabricated system was decorated with folic acid (FA), providing both tumor targeting and imaging. The FA.Cs.ATP@HAP nanoparticles displayed enhanced colloidal stability and controlled drug release. In vitro biological experiments revealed that FA.Cs.ATP@HAP was internalized into the tumor cells with a high efficiency in a time-dependent manner and exhibited strong fluorescence within the cells. Compared with free ATP, the FA.Cs.ATP@HAP nanoparticles exhibited a significant inhibition effect against the proliferation of the tumor cells (Saos-2, T47D, and MCF7) in a dose-dependent manner, while no significant cytotoxic effect was observed in the normal cells (HEK-293), indicating the selective cytotoxicity of the fabricated nanosystem against the tumor cells. Also, the mechanism of action of FA.Cs.ATP@HAP was investigated, and it was found that it induces a high rate of apoptosis in the tumor cells through a decrease in mitochondrial membrane potential and caspase activation. Based on these findings, FA.Cs.ATP@HAP is a novel biomedical material with targeting, imaging, and high anticancer properties against tumor cells, and it could be considered as a promising candidate for cancer therapy.

Keywords

, Mesoporous hydroxyapatite, Adenosine 5′-triphosphate, Chitosan
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@article{paperid:1070025,
author = {Feiz, Mohadese Sadat and Meshkini, Azadeh},
title = {Targeted delivery of adenosine 5′-triphosphate using chitosan-coated mesoporous hydroxyapatite: A theranostic pH-sensitive nanoplatform with enhanced anti-cancer effect},
journal = {International Journal of Biological Macromolecules},
year = {2018},
month = {August},
issn = {0141-8130},
keywords = {Mesoporous hydroxyapatite; Adenosine 5′-triphosphate;Chitosan},
}

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%0 Journal Article
%T Targeted delivery of adenosine 5′-triphosphate using chitosan-coated mesoporous hydroxyapatite: A theranostic pH-sensitive nanoplatform with enhanced anti-cancer effect
%A Feiz, Mohadese Sadat
%A Meshkini, Azadeh
%J International Journal of Biological Macromolecules
%@ 0141-8130
%D 2018

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