Physiology and Pharmacology, Volume (23), No (1), Year (2019-3) , Pages (28-35)

Title : ( Interferon-alpha Reduced Inflammatory Effects of Filgrastim -G-CSF- in Liver of Syrian Mice )

Authors: ENSIEH NAMJOU , Roya Lari , Nasser Mahdavi SHahri , Ali Moghimi ,

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Introduction: granulocyte colony-stimulating factor -G-CSF- has been used widely for the treatment of chemotherapy-induced neutropenia. One of the major side-effects of interferon-α -IFN-α- therapy is neutropenia. Previous studies have confirmed the beneficial effects of co-administration of G-CSF and IFN-α on neutropenia in patients infected with hepatitis C. In this study for the first time, the effects of co-administration of type I IFNs and G-CSF on liver and liver enzymes have been investigated. Materials and methods: forty-two mice -male, eight weeks- were randomly divided into six groups of seven: distilled water, G-CSF -200μg/kg-, interferon alpha -IFN-α- -200μg/kg-, interferon beta -IFN-β- -200μg/kg-, IFN-a+G-CSF, and IFN-b+G-CSF. After 28 days, blood was taken from the heart of each mouse and histological changes in liver and liver enzymes of aspartate transaminase -AST- and alanine transaminase -ALT-, as well as bilirubin, were measured. Results: Surprisingly, in most cases, the G-CSF and type one IFNs alone or simultaneously reduced the levels of AST and bilirubin. The levels of ALT were induced by IFN-α, the addition of G-CSF to IFN-α reduced the level of this liver enzyme. G-CSF induced cell infiltrations into the liver tissue, addition of IFN-α but not IFN-β to G-CSF obviously reduced the cell infiltration into the liver. Conclusions: Since the changes in liver enzymes and bilirubin were not at harmful levels, and the administration of IFN-α to G-CSF reduced the cell infiltrations into the liver, our results suggested that co-administration of type I IFNs and G-CSF had no harmful effects on liver histology and functions.


, Inflammation, IFN-α, IFN-b, G-CSF, Liver, Liver Enzymes.
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author = {NAMJOU, ENSIEH and Lari, Roya and Mahdavi SHahri, Nasser and Moghimi, Ali},
title = {Interferon-alpha Reduced Inflammatory Effects of Filgrastim -G-CSF- in Liver of Syrian Mice},
journal = {Physiology and Pharmacology},
year = {2019},
volume = {23},
number = {1},
month = {March},
issn = {2476-5236},
pages = {28--35},
numpages = {7},
keywords = {Inflammation; IFN-α; IFN-b; G-CSF; Liver; Liver Enzymes.},


%0 Journal Article
%T Interferon-alpha Reduced Inflammatory Effects of Filgrastim -G-CSF- in Liver of Syrian Mice
%A Lari, Roya
%A Mahdavi SHahri, Nasser
%A Moghimi, Ali
%J Physiology and Pharmacology
%@ 2476-5236
%D 2019