Back ground and study aim: Cytokines such as interleukin 23 affects the function of the immune system and different tissues and are studied due to the role they play in MS. The aim of the study was to investigate the effect of exercise in water on plasma interleukin-23 in patient with multiple sclerosis. Materials and methods: 25 men with multiple sclerosis were divided into two groups of exercise and control. Blood sample was taken before and after the protocol. The exercise session was 3 per week for 8 week. The beginning and final stages of each session included warming up and cool down, carried out in shallow areas. These operations were designed and carried out by a researcher under the supervision of a sports physiologist and an experienced neurologist. During the training sessions, 10 minutes of warming up, and the last, 5 minutes of training to cool down were operated. Exercise intensity was approximately 75% of heart rate reserve. Results: demonstrated that in exercise group decreased significantly from pre-test to post-test in MS group. Conclusion: We can conclude that aqua-training may shrink risk factors regarding multiple sclerosis including interleukin23 may improve.

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