Ichthyophthirius multifiliis is a large ciliated protozoan parasite that is widely distributed in freshwater fish. Histone deacetylase inhibitors -HDACi-, e.g., trichostatin A -TSA-, are recognized as new agents for the treatment of a wide range of parasitic diseases. In this study, TSA levels induced by gamma-irradiated trophonts and alginate/calcium phosphate nanoparticles were measured after 30 days following treatment against I. multifiliis in spleen, kidney, and liver tissues of rainbow trout. This sounds like TSA is an anti-parasitic enzyme that can increase in spleen, kidney, and liver tissues following treatment of rainbow trout against I. multifiliis -P < 0.05-. Moreover, the results obtained from this study showed that the TSA activity level is tissue-dependent. The highest significance levels for TSA activity were found in spleen tissue of treated and healthy groups compared with the levels of the both liver and kidney tissues -P < 0.05-.

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