Hyperthermia is a process that involves increasing the temperature of the tumor region, usually up to 43 °C, with the aim of killing cancerous cells. To address the problem of unwanted thermal damage to the healthy tissue around the tumor, the use of nanostructures, as converters of irradiated light into heat energy, has been highly regarded in recent years. In this study, we dealt with the use of MATLAB and COMSOL Multiphysics software to solve the optimization problem regarding laser-induced hyperthermia in the presence of non-uniform distributed gold nanorods. Moreover, the periodic heating method was utilized to solve the problem of surface overheating following applying the optimal laser intensity. Results indicated that the simulated model for subcutaneous tumor treatment with nanoparticle-mediated hyperthermia is consistent with previous computational models. Furthermore, the presented model can optimize the laser power while considers the surface overheating problem.

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