Drug and Chemical Toxicology, ( ISI ), Volume (42), No (3), Year (2019-5) , Pages (300-308)

Title : ( Protective effects of glycyrrhizin on sub-chronic diazinon-induced biochemical, hematological alterations and oxidative stress indices in male Wistar rats )

Authors: asieh karimani , Mohammad Heidarpour , Amir Moghadam Jafari ,

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Abstract

The aim of this study was to elucidate the protective effect of glycyrrhizin on diazinon-induced changes in body and organ weights, blood hematology, lipid profile, biochemistry parameters and tissue markers of oxidative stress in male Wistar rats over a 7-week period. Rats were orally given sublethal dose of diazinon (10 mg/kg daily; 0.008 LD50), while glycyrrhizin (25 mg kg−1 daily) was given alone or in combination with diazinon. At the end of 7th week, statistically significant decrease of pseudocholinesterase activity was detected when diazinon- and glycyrrhizin + diazinon-treated groups were compared to the control group. Diazinon treated rats showed weight loss and organ weight changes which were comparable to other groups. There was a statistically significance in hematological indices except mean corpuscular hemoglobin (MCH) when diazinon treated group was compared to glycyrrhizin + diazinon treated rats. Glycyrrhizin protected the liver and kidney from diazinon toxic effects with significantly decrease in serum aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and lactate dehydrogenase activities as well as ameliorated hepatic and renal function indices (such as bilirubin, total protein, albumin, BUN, creatinine glucose). In addition, glycyrrhizin minimized the hazardous effect of diazinon on plasma lipids and lipoproteins. The protective effects of glycyrrhizin were confirmed by tissue markers of oxidative stress analysis as glycyrrhizin in combination diminished malondialdehyde and glycyrrhizin alone or in combination enhanced thiol group and the ferric reducing power. In accordance to these results, our observations demonstrated the beneficial effects of glycyrrhizin in reducing the toxicity of diazinon.

Keywords

, Glycyrrhizin, diazinon, oxidative stress, hematology, biochemistry, body weight, organ weight
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@article{paperid:1076331,
author = {Karimani, Asieh and Heidarpour, Mohammad and Moghadam Jafari, Amir},
title = {Protective effects of glycyrrhizin on sub-chronic diazinon-induced biochemical, hematological alterations and oxidative stress indices in male Wistar rats},
journal = {Drug and Chemical Toxicology},
year = {2019},
volume = {42},
number = {3},
month = {May},
issn = {0148-0545},
pages = {300--308},
numpages = {8},
keywords = {Glycyrrhizin; diazinon; oxidative stress; hematology; biochemistry; body weight; organ weight},
}

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%0 Journal Article
%T Protective effects of glycyrrhizin on sub-chronic diazinon-induced biochemical, hematological alterations and oxidative stress indices in male Wistar rats
%A Karimani, Asieh
%A Heidarpour, Mohammad
%A Moghadam Jafari, Amir
%J Drug and Chemical Toxicology
%@ 0148-0545
%D 2019

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