24th Iranian and 3rd International Congress of Physiology and Pharmacology , 2019-10-30

Title : ( Effects of Brief Electrical Stimulation on Regeneration of Transected Sciatic Nerve )

Authors: hosein samaram , Nadia Naghavi , sareh nasseri , Morteza Behnam Rassouli ,

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Abstract

Background and Objective: In peripheral nerve injuries, electrical stimulations (ES) have been used to accelerate the nerve regeneration. In this study effects of brief voltage-controlled ES on the functional recovery in a transection model of the rat sciatic nerve has been investigated. Materials and Methods: Fifteen adult male Wistar rats (250-350g) were anesthetized, their right sciatic nerve were transected and randomly divided in one control and two experimental groups (n=5). The proximal and distal ends of the transected nerve were sutured to a 10 mm-long silicone tube and then stimulated as follows; 10 and 30 min ES (20Hz, 3V, 100μs) in experimental groups and no ES in the control group. A hot plate test was done every two week and at the end of the experimental period (12 weeks) the relative nerve conduction velocity (NCV) was measured. Results: Hot plate results indicate that at weeks 8 and 10, the withdraw time in experimental groups are shorter than the control group. However, the differences are not significant. Based on the electrophysiology test, the 10 min-ES group had a significantly higher NCV compared to the control group and the 30 min-ES group (p<0.05). Conclusion: Results demostrated that brief ES can increase the speed of nerve regeneration and also a shorter ES protocol can be more effective while can reduce the chance of infection and the cost of keeping patients under anesthesia.

Keywords

, Peripheral Nerve Regeneration, Voltage-controlled Electrical Pulses, Brief Stimulation
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@inproceedings{paperid:1076596,
author = {Samaram, Hosein and Naghavi, Nadia and Nasseri, Sareh and Behnam Rassouli, Morteza},
title = {Effects of Brief Electrical Stimulation on Regeneration of Transected Sciatic Nerve},
booktitle = {24th Iranian and 3rd International Congress of Physiology and Pharmacology},
year = {2019},
location = {تهران, IRAN},
keywords = {Peripheral Nerve Regeneration; Voltage-controlled Electrical Pulses; Brief Stimulation},
}

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%0 Conference Proceedings
%T Effects of Brief Electrical Stimulation on Regeneration of Transected Sciatic Nerve
%A Samaram, Hosein
%A Naghavi, Nadia
%A Nasseri, Sareh
%A Behnam Rassouli, Morteza
%J 24th Iranian and 3rd International Congress of Physiology and Pharmacology
%D 2019

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