Background and Objective: Diabetes is a chronic disease that occurs as a result of impaired insulin production and function which in turn lead to increase level of blood glucose and many complications. Snake venom is a complex mixture of pharmacologically active compounds. In this study, the effect of Iranian snake, Naja naja oxiana venom on level of blood glucose of diabetic male rats was investigated. Materials and Methods: The combination of nicotinamide (NA) (230 mg/kg) and streptozotocin (STZ) (65 mg/kg) was used to induce type two diabetes (T2D), and STZ (55 mg/kg) alone was used to induce type one diabetes (T1D). After induction of (T2D) in 24 male rats, they were divided into 3 groups: one as control and two other groups received the venom at 0.2 and 0.4 mg/kg. After induction of (T1D) in 16 male rats, one as control and other group received the venom at 0.2 mg/kg. A group of 8 rats received the venom at 0.2 mg/kg for 7 days and then received STZ at 55 mg/kg. Blood glucose level was measured with glucometer and intraperitoneal route (IP) has been used for all injections. Results: The Naja naja oxiana venom significantly reduced the blood glucose in both types (I & II) diabetic rats. The venom has not any effect on level of blood glucose of healthy rats and also unable to prevent the STZ action. Conclusion: The results showed that Naja naja oxiana venom has anti-diabetes effect and can be a potential treatment for diabetes

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