Journal of Drug Delivery Science and Technology, Volume (53), Year (2019-10) , Pages (101200-101212)

Title : ( Synthesis and engineering of mesoporous ZnO@HAP heterostructure as a pH-sensitive nano-photosensitizer for chemo-photodynamic therapy of malignant tumor cells )

Authors: Alireza behnam sani , Azadeh Meshkini ,

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Abstract

The aim of this study was the synthesis of a platform with an optimum physicochemical property and photocatalytic activity for delivery of a standard chemotherapy drug, doxorubicin (Dox). The mesoporous rod-shaped zinc oxide/hydroxyapatite (ZnO@HAP) heterostructures were successfully fabricated and characterized by XRD, FT-IR, FE-SEM, and EDX, and then the nanocomposites with well-defined properties were selected as a nanocarrier for the delivery of Dox. The drug delivery system was decorated with F127 and folic acid (FA), providing a water-soluble system in aqueous medium and targeting effects against tumor cells, respectively. Afterward, Dox was loaded on the surface of the nanocomposites through a single-emulsion solvent-evaporation method. Drug release assessment revealed that proteases cause the release of Dox under a low pH condition, imitating the intracellular compartments like the lysosomes. Based on the biological studies, Dox&FA.F127.ZnO@HAP exerted the most efficient cytotoxic activity against the tumor cells as it was along with the UVA treating. Moreover, it was found that Dox&FA.F127.ZnO@HAP possesses higher cellular uptake efficiency relative to free Dox, particularly in folate-overexpressed tumor cells through clathrin-mediated endocytic pathway. In addition, co-treatment of the tumor cells with Dox&FA.F127.ZnO@HAP and UVA intensified the production of intracellular ROS and drastically enhanced cellular death with mode of apoptosis.

Keywords

, Photodynamic therapy, Zinc oxide, Hydroxyapatite, Chemotherapy, Doxorubicin.
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@article{paperid:1076743,
author = {Behnam Sani, Alireza and Meshkini, Azadeh},
title = {Synthesis and engineering of mesoporous ZnO@HAP heterostructure as a pH-sensitive nano-photosensitizer for chemo-photodynamic therapy of malignant tumor cells},
journal = {Journal of Drug Delivery Science and Technology},
year = {2019},
volume = {53},
month = {October},
issn = {1773-2247},
pages = {101200--101212},
numpages = {12},
keywords = {Photodynamic therapy; Zinc oxide; Hydroxyapatite; Chemotherapy; Doxorubicin.},
}

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%0 Journal Article
%T Synthesis and engineering of mesoporous ZnO@HAP heterostructure as a pH-sensitive nano-photosensitizer for chemo-photodynamic therapy of malignant tumor cells
%A Behnam Sani, Alireza
%A Meshkini, Azadeh
%J Journal of Drug Delivery Science and Technology
%@ 1773-2247
%D 2019

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