Experimental and Molecular Pathology, Volume (89), No (3), Year (2010-12) , Pages (334-342)

Title : ( Chemosensitization of human leukemia K562 cells to taxol by a Vanadium-salen complex )

Authors: Azadeh Meshkini ,

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Abstract

Vanadium complexes are a heterogeneous class of compounds exhibiting interesting biological properties. Herein, we report the effect of a vanadium-salen complex (VO-salen) on proliferative behavior of K562 cell line. The results revealed that VO-salen at 6–32 μM inhibited K562 proliferation with no distinct alteration in cell morphology, extent of apoptosis and/or differentiation. Our results indicated that VO-salen complex has just a cytostatic effect and capable of arresting the affected cells in G2/M phase of cell cycle. In addition, we evaluated the combined effects of VO-salen complex and taxol. The cell cycle analyses showed that VO-salen complex enhanced taxol-induced G2/M arrest and also increased taxol-induced apoptosis through a decrease in the ratio of Bcl-2/Bax which might account for the decrease in the apoptosis threshold among the affected cells. These findings support that combination of VO-salen, as a chemosensitizer, and taxol might constitute an affective new strategy for leukemia therapy.

Keywords

, Apoptosis K562 cell Chemosensitizer Taxol Vanadium, salen complex
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@article{paperid:1077652,
author = {Meshkini, Azadeh},
title = {Chemosensitization of human leukemia K562 cells to taxol by a Vanadium-salen complex},
journal = {Experimental and Molecular Pathology},
year = {2010},
volume = {89},
number = {3},
month = {December},
issn = {0014-4800},
pages = {334--342},
numpages = {8},
keywords = {Apoptosis K562 cell Chemosensitizer Taxol Vanadium-salen complex},
}

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%0 Journal Article
%T Chemosensitization of human leukemia K562 cells to taxol by a Vanadium-salen complex
%A Meshkini, Azadeh
%J Experimental and Molecular Pathology
%@ 0014-4800
%D 2010

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