ABSTRACT (239/250 words) Preptin is a peptide hormone and plays an important role in the development of obesity by regulation of carbohydrate metabolism. Undercarboxylated osteocalcin (ucOCN) is also linked to the regulation of body energy in that it modulates fat and glucose metabolism. This research aimed to examine the impact of aerobic interval, resistance, or concurrent exercise on serum preptin, ucOCN and high molecular weight-adiponectin (HMW-APN) in obese adults with metabolic syndrome (MetS). Forty-four obese men with MetS were randomized to either receive aerobic interval exercise (AIEX, n = 10), resistance exercise (REX, n = 10), or concurrent aerobic interval and resistance exercise (CEX, n = 10) or non-exercise control (CON, n = 10) three times a week for 12 weeks. Preptin reduced more after AIEX and CEX than REX (89.1% and 87.1% versus 9.6%; P=0.028 and 0.030, respectively). UcOCN increased significantly only in the CEX (27.5%, P=0.009) and AIEX (25%, P=0.025) groups. But HMW-APN increased significantly in all three training groups (AIEX 145.1%, P<0.001; CEX 137%, P<0.001; and REX 59.8%, P=0.041). After the intervention, the improvement of peak oxygen uptake (VO2peak) in the AIEX group (73%) was greater than the CEX (29.3%) and REX (3.8%) groups. On the other hand, CEX exhibited a greater reduction in glucose, insulin, insulin resistance index and HbA1c than AIEX and REX. Our study indicates that the reduction in glucose after exercise training (especially AIEX and CEX) maybe, somewhat, linked to decreased preptin and raised ucOCN and HMW-APN. Key words: Bone remodeling; High molecular weight–adiponectin; Metabolic Syndrome; Glucose metabolism; Preptin

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