Iranian Journal of Basic Medical Sciences, ( ISI ), Year (2019-12)

Title : ( The effects of interval aerobic training on mesenchymal biomarker gene expression, the rate of tumor volume, and cachexia in mice with breast cancer )

Authors: Samira Gholamian , Seyyed Reza Attarzadeh Hosseini , Amir Rashidlamir , Hamid Aghaalinjad ,

Citation: BibTeX | EndNote

Abstract

Objective(s): It seems that regular exercise can have inhibitory effects on the progression of breast cancer. This study, therefore, aimed to investigate the influences of interval aerobic training on mesenchymal biomarker gene expression, muscle cachexia, and tumor volume changes in mice with breast cancer. Materials and Methods: Thirty-two female Balb/c mice were allocated to four groups: Exercise Tumor Exercise, Rest Tumor Rest (Control), Rest Tumor Exercise, and Exercise Tumor Rest. Interval aerobic training was done 6 weeks before and 4 weeks after tumor induction. Weight test and inverted screen test were carried out as muscle function tests. Data were analyzed using one-way ANOVA and HSD post hoc. Results: The results showed a significant decrease in gene expressions of Twist, Vimentin, and TGF-β in Exercise Tumor Exercise group in comparison with the Control group (P<0.05). Remarkable reduction of the rate of tumor volume was also observed in two training groups (Rest Tumor Exercise, Exercise Tumor Exercise) compared with the control group. According to function tests’ results, muscle functions were diminished due to cancer, but interval aerobic training can keep muscles in a normally-functioning state in cancer (P<0.05). Conclusion: Considering final results, a period of interval aerobic training can be used not only as a prevention method, but also help cancer treatment and impede cachexia by tumor volume reduction, decrease mesenchymal biomarker gene expression, and increase muscle strength functions.

Keywords

, Breast cancer Cachexia Interval aerobic training TGF, β Tumor Volume Twist Vimentin
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@article{paperid:1078013,
author = {Gholamian, Samira and Attarzadeh Hosseini, Seyyed Reza and Rashidlamir, Amir and Hamid Aghaalinjad},
title = {The effects of interval aerobic training on mesenchymal biomarker gene expression, the rate of tumor volume, and cachexia in mice with breast cancer},
journal = {Iranian Journal of Basic Medical Sciences},
year = {2019},
month = {December},
issn = {2008-3866},
keywords = {Breast cancer Cachexia Interval aerobic training TGF-β Tumor Volume Twist Vimentin},
}

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%0 Journal Article
%T The effects of interval aerobic training on mesenchymal biomarker gene expression, the rate of tumor volume, and cachexia in mice with breast cancer
%A Gholamian, Samira
%A Attarzadeh Hosseini, Seyyed Reza
%A Rashidlamir, Amir
%A Hamid Aghaalinjad
%J Iranian Journal of Basic Medical Sciences
%@ 2008-3866
%D 2019

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