Title : ( Osteoconductive composite graft based on bacterial synthesized hydroxyapatite nanoparticles doped with different ions: From synthesis to in vivo studies )
Authors: Ahmadzad E , Talebnia F , Tabatabaei M , Hossein Ahmadzadeh , Mostaghaci B ,
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Abstract
To repair damaged bone tissues, osteoconductive bone graft substitutesare required for enhancement of the regenerative potential of osteoblast cells. Nanostructured hydroxyapatite is a bioactive ceramic used for bone tissue engineering purposes. In this study, carbonate hydroxyapatite (cHA) and zinc-magnesium substituted hydroxyapatite (Zn-Mg-HA) nanoparticles were synthesized via biomineralization method using Enterobacter aerogenes. The structural phase composition and the morphology of the samples were analyzed using appropriate powder characterization methods. Next, a composite graft was fabricated by using polyvinyl alcohol and both cHA and Zn-Mg-HA samples. In vivo osteogenic potential of the graft was then investigated in a rabbit tibial osteotomy model. Histological, radiological and morphological studies showed that the graft was mineralized by the newly formed bone tissue without signs of inflammation or infection after 4 weeks of implantation. These histomorphometric results suggest that the fabricated graft can function as a potent osteoconductive bone tissue substitute.
Keywords
, Bone graft, hydroxyapatite, nanoparticles, biomineralization, tissue engineering
@article{paperid:1078390,
author = {الهام احمدزاده and فرید طالب نیا and میثم طباطبایی and Ahmadzadeh, Hossein and Mostaghaci B},
title = {Osteoconductive composite graft based on bacterial synthesized hydroxyapatite nanoparticles doped with different ions: From synthesis to in vivo studies},
journal = {Nanomedicine: Nanotechnology, Biology and Medicine},
year = {2016},
volume = {12},
number = {5},
month = {July},
issn = {1549-9634},
pages = {1387--1395},
numpages = {8},
keywords = {Bone graft; hydroxyapatite; nanoparticles; biomineralization; tissue engineering},
}
%0 Journal Article
%T Osteoconductive composite graft based on bacterial synthesized hydroxyapatite nanoparticles doped with different ions: From synthesis to in vivo studies
%A الهام احمدزاده
%A فرید طالب نیا
%A میثم طباطبایی
%A Ahmadzadeh, Hossein
%A Mostaghaci B
%J Nanomedicine: Nanotechnology, Biology and Medicine
%@ 1549-9634
%D 2016
