Aims: Secreted frizzled related protein 5 (SFRP5) and Wnt family member 5A (WNT5A) have been found to associate with glucose metabolism and insulin sensitivity through noncanonical WNT signaling. The purpose of this study was to investigate changes in SFRP5, WNT5A, glycated hemoglobin (HbA1c), body mass index (BMI), percentage body fat (PBF) and insulin resistance in men with type 2 diabetes after 12 weeks of combined exercise (high intensity interval training (HIIT) and resistance) and examine the relationship between these variables in men with type 2 diabetes. Methods: 19 men with type 2 diabetes (mean age of 58.3) were divided into two groups: experimental group (10 individuals) and control group (9 individuals). The experimental group performed 12 weeks of combined exercise (HIIT and resistance). Results: 12 weeks of combined exercise (HIIT and resistance) increased SFRP5 serum level and decreased WNT5A serum level, HbA1c, insulin resistance, BMI, and PBF in the intervention group compared to the control group. SFRP5 had a significant negative relationship with WNT5A, insulin resistance, BMI, and PBF. In addition, BMI had a significant positive relationship with WNT5A, insulin resistance, and PBF. Conclusion: The improvement of type 2 diabetic men’s health can be a result of increased anti-inflammatory factor SFRP5 and decreased inflammatory factor WNT5a through reduction of BMI and PBF.

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