Materials, Volume (12), No (22), Year (2019-11) , Pages (3696-3713)

Title : ( Functionalization and Surface Modifications of Bioactive Glasses (BGs): Tailoring of the Biological Response Working on the Outermost Surface Layer )

Authors: Saeid Kargozar , Farzad Kermani , Sahar Mollazadeh Beidokhti , Sepideh Hamzehlou , Enrica Verne , Sara Ferraris , Francesco Baino ,

Citation: BibTeX | EndNote

Abstract

Bioactive glasses (BGs) are routinely being used as potent materials for hard and soft tissue engineering applications; however, improving their biological activities through surface functionalization and modification has been underestimated so far. The surface characteristics of BGs are key factors in determining the success of any implanted BG-based material in vivo since they regulate the affinity and binding of different biological macromolecules and thereby the interactions between cells and the implant. Therefore, a number of strategies using chemical agents (e.g., glutaraldehyde, silanes) and physical methods (e.g., laser treatment) have been evaluated and applied to design properly, tailor, and improve the surface properties of BGs. All these approaches aim at enhancing the biological activities of BGs, including the induction of cell proliferation and subsequent osteogenesis, as well as the inhibition of bacterial growth and adhesion, thereby reducing infection. In this study, we present an overview of the currently used approaches of surface functionalization and modifications of BGs, along with discussing the biological outputs induced by these changes.

Keywords

bioactive glasses; surface modifications; functionalization; bioactivity; bone tissue engineering
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@article{paperid:1078640,
author = {Saeid Kargozar and Kermani, Farzad and Mollazadeh Beidokhti, Sahar and Sepideh Hamzehlou and Enrica Verne and Sara Ferraris and Francesco Baino},
title = {Functionalization and Surface Modifications of Bioactive Glasses (BGs): Tailoring of the Biological Response Working on the Outermost Surface Layer},
journal = {Materials},
year = {2019},
volume = {12},
number = {22},
month = {November},
issn = {1996-1944},
pages = {3696--3713},
numpages = {17},
keywords = {bioactive glasses; surface modifications; functionalization; bioactivity; bone tissue engineering},
}

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%0 Journal Article
%T Functionalization and Surface Modifications of Bioactive Glasses (BGs): Tailoring of the Biological Response Working on the Outermost Surface Layer
%A Saeid Kargozar
%A Kermani, Farzad
%A Mollazadeh Beidokhti, Sahar
%A Sepideh Hamzehlou
%A Enrica Verne
%A Sara Ferraris
%A Francesco Baino
%J Materials
%@ 1996-1944
%D 2019

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