Background: Today, substance abuse, drug addiction and alcohol are among the most common psychiatric disorders in the general population. Therefore, consideration of what is affecting the general health of addicts and their families, especially their children, is inevitable. Aim: The objective of this study is to compare the inluence of parents addiction on the psychological well-being, stress, depression, and anxiety of their offspring by selecting group samples of people whose parents are with or without substance abuse. Methods: To achieve this goal, descriptive, correlation and causal comparative methods were used. The statistical population of this study included 250 people; 120 of these individuals had at least one parent with drug addiction, while the remaining 130 had non-addicted parents. They were selected using the available sampling method. Results: The outcomes showed that there was a significant difference in psychological well being between children with and without addicted parents (mean for addicted parents: 8.30, for non-addicted parents: 4.75, p=.000). Conclusion: The depression, anxiety and stress scores of children who have addicted parents were signijcantly higher than those of the children with non-addicted parents, which is consistent with the results of other studies in this area. Therefore, by recognizing and exploring the role of parents addiction and other factors, such as addicted friends, proactive programmes can be implemented for those parents’ children.

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