Materials Science and Engineering C, ( ISI ), Volume (111), No (1), Year (2020-6) , Pages (110828-110846)

Title : ( Silicon-doped calcium phosphates; the critical effect of synthesis routes on the biological performance )

Authors: Farzad Kermani , Amir Masoud Gharavian , Sahar Mollazadeh Beidokhti , Saeed Kargozar , Abbas Youssefi , Jalil Vahdati Khaki ,

Citation: BibTeX | EndNote

Abstract

In this study, the effect of using different types of fuel and various amounts of Si4+ ions on the biological properties of silicon-doped calcium phosphates (CaPs), which were synthesized using solution combustion method were investigated. X-ray diffraction (XRD) patterns showed that hydroxyapatite/beta-tricalcium phosphate (HA/βTCP) was crystallized in all synthesized samples. The synthesized sample using glycine as fuel, which doped with 0.1 mol Si4+ ions exhibited the most desirable properties. Consecutively, the zeta potential and specific surface area were enhanced from −20 to −27 mV and 38 to 146 m2/g, respectively, by increasing the amount of Si4+ ions from 0 to 0.1 mol. The bioactivity of the samples immersed in simulated body fluid (SBF) was innovatively determined by the joint analyses of the tensiometer, inductively coupled plasma (ICP), field emission scanning electron microscopy (FESEM), and XRD data. These findings plus theoretical calculations demonstrate, for the first time, that the Si4+ doping could improve the bioactivity of the powders up to ~155%. The results of in vitro cell-based experiments, including cell viability, alizarin red staining, and cell attachment, confirmed the positive effects of Si-doped powders in the biological systems. Furthermore, Si-doped powders were able to improve the migration ability of mammalian cells in vitro; they could be considered good candidates in angiogenesis-based therapeutic strategies.

Keywords

Calcium phosphates Silicon ions (Si4+) substitution Solution combustion synthesis In vitro properties Tissue engineering
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@article{paperid:1081234,
author = {Kermani, Farzad and Gharavian, Amir Masoud and Mollazadeh Beidokhti, Sahar and Saeed Kargozar and Abbas Youssefi and Vahdati Khaki, Jalil},
title = {Silicon-doped calcium phosphates; the critical effect of synthesis routes on the biological performance},
journal = {Materials Science and Engineering C},
year = {2020},
volume = {111},
number = {1},
month = {June},
issn = {0928-4931},
pages = {110828--110846},
numpages = {18},
keywords = {Calcium phosphates Silicon ions (Si4+) substitution Solution combustion synthesis In vitro properties Tissue engineering},
}

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%0 Journal Article
%T Silicon-doped calcium phosphates; the critical effect of synthesis routes on the biological performance
%A Kermani, Farzad
%A Gharavian, Amir Masoud
%A Mollazadeh Beidokhti, Sahar
%A Saeed Kargozar
%A Abbas Youssefi
%A Vahdati Khaki, Jalil
%J Materials Science and Engineering C
%@ 0928-4931
%D 2020

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