Journal of Kermanshah University of Medical Sciences, Volume (24), No (3), Year (2020-11) , Pages (1-6)
Title : ( Peroxisome proliferator-activated receptor gamma coactivator 1-alpha and Sirtuin 1 Protein Concentration in Soleus Muscle are Regulated via Aerobic Exercise training in Obese Wistar Rats )
Authors: keyvan Hejazi , Seyyed Reza Attarzadeh Hosseini , Mehrdad Fathei , Mohammad Mosaferi Ziaaldini ,
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Abstract
Objectives: Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1a) and Sirtuin 1 (SIRT1) are significant indicators playing a part in obesity and other metabolic disorders. The aim of this study was to investigate the effects of eight weeks aerobic training with different intensities on levels of PGC-1a and SIRT1 in obese male rats.Methods: 24 obese male rats were randomly put into three groups including control group, medium-intensity training group (28 m per minute) and high-intensity training group (34 m per minute) after obesity induction through maintaining a high-fat diet.
