Title : ( Novel Tricyclic 2-Alkoxy-8-methyl-6-(pyrrolidin-1-yl)-4H-[1,2,4]triazolo[5,1-f]purine Derivatives: Synthesis and Characterization )
Authors: sara bigonah rasti , Seddigheh Sheikhi-Mohammareh , Kayvan Saadat , Ali Shiri ,
Full TextAbstract
A convenient approach for the synthesis of diversely functionalized[1,2,4]triazolo[5,1-f]purine heterocyclic framework have been accomplished. The products were obtained through the combination of 5-amino-3-(methylthio)-1H-1,2,4-triazole with 5-bromo-2,4-dichloro-6-methylpyrimidine followed by a SNAr alkoxylation of the novel tricyclic heterocyclic core with various aliphatic alcohols. All newly synthesized heterocycles were fully elucidated by both computational and spectral evaluations.
Keywords
, [1, 2, 4]Triazolo[5, 1-f]purine; 5-amino-3-(methylthio)-1H-1, 2, 4-triazole; 5-bromo-2, 4-dichloro-6-methylpyrimidine; computational evaluations; heterocyclization
@article{paperid:1082376,
author = {Bigonah Rasti, Sara and Sheikhi-Mohammareh, Seddigheh and Saadat, Kayvan and Shiri, Ali},
title = {Novel Tricyclic 2-Alkoxy-8-methyl-6-(pyrrolidin-1-yl)-4H-[1,2,4]triazolo[5,1-f]purine Derivatives: Synthesis and Characterization},
journal = {Polycyclic Aromatic Compounds},
year = {2020},
volume = {42},
number = {5},
month = {December},
issn = {1040-6638},
pages = {2644--2654},
numpages = {10},
keywords = {[1;2;4]Triazolo[5;1-f]purine; 5-amino-3-(methylthio)-1H-1;2;4-triazole; 5-bromo-2;4-dichloro-6-methylpyrimidine; computational evaluations; heterocyclization},
}
%0 Journal Article
%T Novel Tricyclic 2-Alkoxy-8-methyl-6-(pyrrolidin-1-yl)-4H-[1,2,4]triazolo[5,1-f]purine Derivatives: Synthesis and Characterization
%A Bigonah Rasti, Sara
%A Sheikhi-Mohammareh, Seddigheh
%A Saadat, Kayvan
%A Shiri, Ali
%J Polycyclic Aromatic Compounds
%@ 1040-6638
%D 2020
