Bulgarian Journal Of Veterinary Medicine, ( ISI ), Volume (24), No (2), Year (2021-1) , Pages (200-207)

Title : ( Evaluation of MexAB-OprM efflux pump and determination of antimicrobial susceptibility in Pseudomonas aeruginosa human and veterinary isolates )

Authors: Niloufar Mohseni , Mehrnaz Rad , Babak KHoramian Toosi , A. R.MOKHTARI , R. YAHYARAEYAT , T. ZAHRAIE SALEHI ,

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Abstract

Pseudomona aeruginosa could cause serious infections in hospitals and is highlighted as a source of financial problems in farms. The revelation of drug resistant, particularly multi-drug resistant (MDR)P. aeruginosa is important around the world. The efflux pump activity is identified as one of the most important intrinsic resistant mechanisms in P. aeruginosa. A total of 96 P. aeruginosa isolates from inpatient and animal sources were tested for antimicrobial susceptibility and subjected to multiplex PCR (mPCR) assay to detect MexAB-OprM efflux pump system. The human isolates have shown the highest resistance against cefazolin, ampicillin, nalidixic acid, trimethoprim/sulfamethoxazole, cepha-lothin, oxacillin (100%). All farm animal isolates were resistant to cefazolin, kanamycin, amoxicillin clavulanic acid, and cephalothin (100%). In both isolate groups, the presence of MexA was more common than that of MexB.MexAB-OprM was demonstrated as a valuable mechanism in P. aerugi-nosa antimicrobial resistant strains.

Keywords

, antimicrobial susceptibility, efflux pump, MexAB-OprM, multiplex PCR, Pseudomonas aeruginosa
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@article{paperid:1084407,
author = {Mohseni, Niloufar and Rad, Mehrnaz and KHoramian Toosi, Babak and A. R.MOKHTARI and R. YAHYARAEYAT and T. ZAHRAIE SALEHI},
title = {Evaluation of MexAB-OprM efflux pump and determination of antimicrobial susceptibility in Pseudomonas aeruginosa human and veterinary isolates},
journal = {Bulgarian Journal Of Veterinary Medicine},
year = {2021},
volume = {24},
number = {2},
month = {January},
issn = {1311-1477},
pages = {200--207},
numpages = {7},
keywords = {antimicrobial susceptibility; efflux pump; MexAB-OprM; multiplex PCR; Pseudomonas aeruginosa},
}

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%0 Journal Article
%T Evaluation of MexAB-OprM efflux pump and determination of antimicrobial susceptibility in Pseudomonas aeruginosa human and veterinary isolates
%A Mohseni, Niloufar
%A Rad, Mehrnaz
%A KHoramian Toosi, Babak
%A A. R.MOKHTARI
%A R. YAHYARAEYAT
%A T. ZAHRAIE SALEHI
%J Bulgarian Journal Of Veterinary Medicine
%@ 1311-1477
%D 2021

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