Title : ( Sono-synthesis approach improves anticancer activity of ZnO nanoparticles: reactive oxygen species depletion for killing human osteosarcoma cells )
Authors: Mansoureh Parsa , Mohammad Hassan Entezari , Azadeh Meshkini ,
Full TextAbstract
Aim: To investigate the effect of ultrasound during the synthesis of ZnO nanoparticles (NPs) on their anticancer activity. Materials & methods: ZnO NPs were synthesized in the presence and absence of ultrasonic irradiation. Biological tests were performed on human osteosarcoma cancer cells (Saos-2). Results: The sono-synthesized sample indicated higher cytotoxicity than the conventional one. (IC50 = 16.48 ± 0.41μg/ml for sonochemical ZnO; 26.96 ± 0.33 μg/ml for conventional ZnO). Both sonochemical and conventional samples acted like antioxidants and reduced intracellular reactive oxygen species level. This reduction was more significant in cells treated with the sono-synthesized sample. The sono-synthesized ZnO NPs showed more tumor selectivity than the conventional sample. Conclusion: Sono-synthesis of ZnO NPs by a bath sonicator could improve their anticancer activity.
Keywords
, anticancer activity • intracellular ROS • sono, synthesized ZnO NPs • tumor, selective cytotoxicity • ultrasonic bath
@article{paperid:1084649,
author = {Parsa, Mansoureh and Entezari, Mohammad Hassan and Meshkini, Azadeh},
title = {Sono-synthesis approach improves anticancer activity of ZnO nanoparticles: reactive oxygen species depletion for killing human osteosarcoma cells},
journal = {Nanomedicine},
year = {2021},
volume = {16},
number = {8},
month = {April},
issn = {1743-5889},
pages = {657--671},
numpages = {14},
keywords = {anticancer activity • intracellular ROS • sono-synthesized ZnO NPs • tumor-selective cytotoxicity
• ultrasonic bath},
}
%0 Journal Article
%T Sono-synthesis approach improves anticancer activity of ZnO nanoparticles: reactive oxygen species depletion for killing human osteosarcoma cells
%A Parsa, Mansoureh
%A Entezari, Mohammad Hassan
%A Meshkini, Azadeh
%J Nanomedicine
%@ 1743-5889
%D 2021
