Despite significant advances in left ventricular assist devices and the cannula, unfavorable events leading to the death of patients, including bleeding, infection, neurological disorders, hemolysis, and thrombosis, are still being reported. Local parameters of blood flow, including static flow, vorticity and critical values of shear stress on the wall of ventricle and cannula, increase the risk of thrombosis. Therefore, the analysis of blood flow domains inside the ventricle and cannula is necessary to investigate the probability of forming thrombosis in the cannula of left ventricular assist devices. In this study, blood flow is investigated in a Medtronic DLP 16F clinical cannula by using computational fluid dynamics through three-dimensional modeling of the left ventricle and cannula based on real geometry. Apart from the fact that blood is considered non-Newtonian fluid, the effect of heart movement in the left ventricle is also applied. In this research, blood flow in the cannula has been examined and some problems resulting from the use of the cannulas have been investigated. The results indicate that changing the geometry of input holes, such as their number and size, on the tip of the cannula, alter the probability of forming thrombosis and the standard mode shows a better performance.

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