Molecular Biology Reports, Volume (48), No (3), Year (2021-3) , Pages (2273-2284)

Title : ( Investigating the association between rs6983267 polymorphism and susceptibility to gastrointestinal cancers in Iranian population )

Authors: farzaneh karimi , Seyede Mina Amiri , zakieh baghery ghoozhdi , Ahmad Reza Bahrami , Ladan Goshayeshi , Abolghasem Allahyari , Marjane Mirsadraee , Azar Fanipakdel , Alireza Bari , Ali Emadi-Torghabeh , Mohammad Amin Kerachian , Hossein Rahimi , Maryam Moghaddam Matin ,

Citation: BibTeX | EndNote

Abstract

Genome-wide association studies have revealed that some single nucleotide polymorphisms at 8q24, such as rs6983267, might be effective in susceptibility to various cancers in different populations. Therefore, rs6983267 might be useful as a marker for multiple cancers. In this study, we considered a population, including 478 gastrointestinal cancer cases from the Iranian population, to investigate the association between rs6983267 and susceptibility to gastrointestinal cancers. The samples were genotyped using the TaqMan real-time PCR method while 10% of them were also confirmed by sequencing. Higher frequency of G allele was associated with higher grades of tumors in esophageal cancer and the tumors located in the lower portion of the esophagus (OR 3.56; 95% CI 1.13–11.24; P = 0.03) and cardia (OR 5.24; 95% CI 1.26–21.83; P = 0.02), which both locations are involved in esophageal adenocarcinomas with poor prognosis. The results indicated that in the male subgroup, the rs6983267 GG genotype significantly enhanced the gastric cancer susceptibility (OR 4.76; 95% CI 1.57–14.45; P = 0.01). GG genotype also increased the risk of intestinal-type gastric cancer, located in non-cardia (OR 4.62; 95% CI 1.25–17.04; P = 0.02). Moreover, gastric cancer cases and controls with a family history of gastrointestinal tumors were mostly genotyped with the G allele (OR 3.61; 95% CI = 1.09–12.01; P = 0.04). There were no remarkable associations between rs6983267 and susceptibility to esophageal and colon cancers in the Iranian population. However, different genotypes of rs6983267 had significant correlations with tumor grade, cancer type, and family history of gastrointestinal cancers. Further investigations in a larger population and other ethnicities are required to confirm these results.

Keywords

8q24; CCAT2; Gastrointestinal cancers; Polymorphism; Rs6983267
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@article{paperid:1086335,
author = {Karimi, Farzaneh and Amiri, Seyede Mina and Baghery Ghoozhdi, Zakieh and Bahrami, Ahmad Reza and Ladan Goshayeshi and Abolghasem Allahyari and Marjane Mirsadraee and Azar Fanipakdel and Alireza Bari and Ali Emadi-Torghabeh and Mohammad Amin Kerachian and Hossein Rahimi and Moghaddam Matin, Maryam},
title = {Investigating the association between rs6983267 polymorphism and susceptibility to gastrointestinal cancers in Iranian population},
journal = {Molecular Biology Reports},
year = {2021},
volume = {48},
number = {3},
month = {March},
issn = {0301-4851},
pages = {2273--2284},
numpages = {11},
keywords = {8q24; CCAT2; Gastrointestinal cancers; Polymorphism; Rs6983267},
}

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%0 Journal Article
%T Investigating the association between rs6983267 polymorphism and susceptibility to gastrointestinal cancers in Iranian population
%A Karimi, Farzaneh
%A Amiri, Seyede Mina
%A Baghery Ghoozhdi, Zakieh
%A Bahrami, Ahmad Reza
%A Ladan Goshayeshi
%A Abolghasem Allahyari
%A Marjane Mirsadraee
%A Azar Fanipakdel
%A Alireza Bari
%A Ali Emadi-Torghabeh
%A Mohammad Amin Kerachian
%A Hossein Rahimi
%A Moghaddam Matin, Maryam
%J Molecular Biology Reports
%@ 0301-4851
%D 2021

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