Abstract The detoxification effects of dietary Spirulina platensis were investigated through semi-static chronic toxicity test developed with potassium cyanide (KCN) in common carp (Cyprinus carpio). The addition of dried Spirulina platensis in diet improves the hematological parameters (mean cell hemoglobin (MCH), hemoglobin (Hb), and mean cell hemoglobin concentrations (MCHC)) in spirulina + cyanide (SC) group in comparison with the fish exposed to cyanide alone (CY). RBC count increased in fish fed with spirulina (SP) in comparison with the other groups. However, this increase was significant compared with SC and CY (P<0.05). hematocrit (HCT), MCHC, and Hb level showed no significant difference among groups (P>0.05). MCH level improved significantly in the SC group compared with the SP group (P<0.05). Mean corpuscular volume (MCV) level had its highest level in the CY group compared with the SP group. WBC count increased significantly in the SC group compared to the CY group (P<0.05). To sum up, it seems that, 10 % S. platensis in diet provided some protections against the toxic action of KCN and increased the chance of blood regeneration.

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