The use of sports supplements is increasing, HMB supplementation is caused by a change in the branched-chain amino acid leucine (1). Liver enzymes, lactate dehydrogenase (LDH), creatine kinase (CK) have been shown to increase in the blood when muscle damage occurs, so changes in the concentration of these enzymes can cause muscle damage. Studies have shown that 1.5 to 3 grams of HMB per day reduces muscle proteolysis and increases muscle strength and volume after 3-8 weeks of strength training (1, 2), Patterson et al. (2008) showed hepatic effects. Intense physical activity can be detected in the serum for up to 7 days (3). Due to the fact that enzymes such as AST and ALT are found in other tissues such as skeletal muscle in addition to the liver (4) and also considering the effect of HMB in preventing muscle damage, the present study was dedicated to this issue. materials and methods: The use of sports supplements is increasing, HMB supplementation is caused by a change in the branched-chain amino acid leucine (1). Liver enzymes, lactate dehydrogenase (LDH), creatine kinase (CK) have been shown to increase in the blood when muscle damage occurs, so changes in the concentration of these enzymes can cause muscle damage. Studies have shown that 1.5 to 3 grams of HMB per day reduces muscle proteolysis and increases muscle strength and volume after 3-8 weeks of strength training (1, 2), Patterson et al. (2008) showed hepatic effects. Intense physical activity can be detected in the serum for up to 7 days (3). Due to the fact that enzymes such as AST and ALT are found in other tissues such as skeletal muscle in addition to the liver (4) and also considering the effect of HMB in preventing muscle damage, the present study was dedicated to this issue. Discussion and conclusion The results show that one session of intense resistance activity increases the levels of liver enzymes, but the use of HMB before intense resistance exercise does not have a significant effect on the values of these indicators. The findings of the present study are consistent with the findings of Peterson et al. (2007) (3). The consequence of intense sports activities, especially activities with extroverted contractions, is muscle damage in skeletal muscles, which is associated with increased serum enzymatic levels (6). More research seems to be needed to determine the effect of HMB over longer periods of use or in other areas of training, especially in trained athletes. Consumption of HMB is probably associated with a significant increase in muscle volume and strength and a reduction in muscle damage, and may also increase aerobic capacity.

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