BACKGROUND: The purpose of this study was to investigate the effect of six-month aerobic exercise during dialysis on hepatic enzymes, cystatin c, glomerular filtration factors and the quality of life of hemodialysis patients. METHODS: The subjects of this study were 30 subjects randomly divided into two groups including experimental groups (N.=15) and control (N.=15). The aerobic exercise program consisted of six months of aerobic exercise, 3 sessions per week, and each session for 30 to 45 minutes with a maximum intensity of 50-70% of the maximum heart rate stored on the minibike. Paired sample t-test and repeated measures (ANOVA) were used to compare between- and within-group variance changes. Significance level was considered less than 0.05. RESULTS: Mass loss, Body Mass Index, body fat percentage, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, cystatin C significantly decreased while the maximum oxygen consumption at the end of the period increased significantly. Changes in intragroup mean in physical, psychological, general health, vitality, social activity, physical function, emotional function, and life satisfaction in the group of men with kidney disease increased significantly at the end of the training period. Phosphorus, calcium, sodium, potassium, urea, creatinine and bilirubin levels decreased significantly. CONCLUSIONS: The results indicate the positive effects of using aerobic exercise as a noninvasive and non-pharmacological method with minimal side effects that can be effective in improving the renal function of these patients. Therefore, due to this, this method can probably beused to improve the condition of patients under hemodialysis. (Cite this article as: Fathi M, Hejazi K. The effect of six months aerobic exercise during dialysis on liver enzymes, cystatin C and quality of life of hemodialysis patients.

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