Title : ( Synthesis of functionalized pyrrole derivatives via diverse cyclization of azomethine ylide and olefins )
Authors: saman sayebani , Hossein Eshghi , ,
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Abstract
The azomethine ylides are generally used in 1,3-dipolar cycloadditions with various dipolarophiles. In this work, a new and diverse route has been developed for the azomethine ylides, for synthesis of novel pyrrole derivatives. The azomethine ylide, produced via C–H activation of unreactive C(sp3)–H bond of 2-methylquinoline, by molecular iodine, in the presence of pyridine. Herein, we represent novel pyrrole derivatives, synthesized from the reaction of pyridinium ylide with olefins, which formed via a reaction of isatin, dialkyl acetylenedicarboxylate derivatives and pyridine as a base in moderate to excellent yields. Various features of this cyclization, discussed.
Keywords
, Diverse cyclization reaction · Azomethine ylide · Pyrrole, based scaffolds · Pyridine · Tandem reaction
@article{paperid:1086801,
author = {Sayebani, Saman and Eshghi, Hossein and , },
title = {Synthesis of functionalized pyrrole derivatives via diverse cyclization of azomethine ylide and olefins},
journal = {Molecular Diversity},
year = {2021},
volume = {26},
number = {4},
month = {October},
issn = {1381-1991},
pages = {2221--2230},
numpages = {9},
keywords = {Diverse cyclization reaction · Azomethine ylide · Pyrrole-based scaffolds · Pyridine · Tandem reaction},
}
%0 Journal Article
%T Synthesis of functionalized pyrrole derivatives via diverse cyclization of azomethine ylide and olefins
%A Sayebani, Saman
%A Eshghi, Hossein
%A ,
%J Molecular Diversity
%@ 1381-1991
%D 2021
