Aim: Sensitive peripheral neuropathy is one of the most common complications of type 1 and type 2 diabetes as a sign of progression of the disease. Extracellular signal-regulated kinases (ERK) and p38 and of course JNK are MAPKs that are involved in the development of neuropathic pain and induce pain sensitivity.therefore, the present study aimed to investigate and compare the effect of high intensity interval training and aerobic exercise on some of Stress- Activated Protein Kinases such as p38 and NF-Kβ,JNK and glucose in type II diabetic men with peripheral neuropathy. Methods: This research is fundamental in purpose and in terms of empirical data collection. The number of patients were36people .this research has done in zahedan. Subjects randomly divided into three groups of intensity interval training and aerobic exercise and one control group. Subjects presentedm at the protocol site prior to the start of the exercise program for some initial assessments and measurements.Results: The normality of the data distribution has done by k-s and ANOVA with repeated measures was used to study the significant differences between groups . Data analysis was performed using SPSS software version 21 .Conclusion:The results showed that the positive effect of exercise on studied factors although,the intense interval training is more effective

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