Comparative Clinical Pathology, ( ISI ), Volume (31), No (1), Year (2022-2) , Pages (109-114)

Title : ( Evaluation of mice testosterone and sperm parameters affected with Crocin )

Authors: AZHAAR HUSSIEN , Ahmad Ali Mohammadpour , Abbas Parham ,

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In this study, 32 adult male mice were divided into four groups (8 in each group), control (received normal saline) and the three experimental groups (received Crocin 4, 20,100 mg/kg every day) for 6 weeks. At the end of the experiment, blood testosterone level was analyzed by enzyme immunoassay and sperm parameters (count, motility, and viability) were evaluated. Data were analyzed by one-way ANOVA, using SPSS software. After administration of Crocin at a dosage of 100 mg/ kg, the results clearly showed that the number of sperm was significantly reduced compared to the control. In experimental groups (20 and 100 mg/kg), a significant increase in testosterone levels in blood serum compared to the control group was shown. But, in the Crocin group (4 mg/kg), no significant difference in testosterone levels than the control group was shown. Compared with the control group, the average testosterone level of the Crocin group (20 mg/kg) was significantly increased. In conclusion, higher doses (100 mg/kg) of Crocin administration may negatively affect the reproductive system by reducing sperm count, sperm motility, and testicular damage. However, a relatively safe dose of Crocin (20 mg/kg) is required in clinical trials.


Crocin · Mice · Sperm parameter · Testosterone
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author = {HUSSIEN, AZHAAR and Mohammadpour, Ahmad Ali and Parham, Abbas},
title = {Evaluation of mice testosterone and sperm parameters affected with Crocin},
journal = {Comparative Clinical Pathology},
year = {2022},
volume = {31},
number = {1},
month = {February},
issn = {1618-5641},
pages = {109--114},
numpages = {5},
keywords = {Crocin · Mice · Sperm parameter · Testosterone},


%0 Journal Article
%T Evaluation of mice testosterone and sperm parameters affected with Crocin
%A Mohammadpour, Ahmad Ali
%A Parham, Abbas
%J Comparative Clinical Pathology
%@ 1618-5641
%D 2022