Title : ( Effect of immobilization, mutation, and microbial stresses on increasing production efficiency of “Cyclosporin A” )
Authors: Fereshteh Falah , , Mohammad Ramezani , Farideh Tabatabaei yazdi , Sayed Ali Mortazavi , Abolghasem Danesh ,
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Abstract
Cyclosporin A (CyA) is a secondary metabolite mainly produced by Tolypocladium inflatum. CyA is a non-polar cyclic polypeptide that is widely used in medicine. Its importance is due to its immunosuppressive role making it useful for the treatment of autoimmune diseases, although to some extent, it showed anti-fungal and anti-parasitic properties. In this review, we discuss the biosynthetic pathway, fermentative production (increasing production efficiency by cells, appropriate, and new fermentation process), downstream processing (efficient extraction and purification), and harmacological activities of CyA.
Keywords
Cyclosporin A · Fermentation · Mutation · Immobilization · Purification
@article{paperid:1089327,
author = {Falah, Fereshteh and , and Mohammad Ramezani and Tabatabaei Yazdi, Farideh and Mortazavi, Sayed Ali and Abolghasem Danesh},
title = {Effect of immobilization, mutation, and microbial stresses on increasing production efficiency of “Cyclosporin A”},
journal = {Biomass Conversion and Biorefinery},
year = {2022},
volume = {14},
number = {4},
month = {March},
issn = {2190-6815},
pages = {4441--4456},
numpages = {15},
keywords = {Cyclosporin A · Fermentation · Mutation · Immobilization · Purification},
}
%0 Journal Article
%T Effect of immobilization, mutation, and microbial stresses on increasing production efficiency of “Cyclosporin A”
%A Falah, Fereshteh
%A ,
%A Mohammad Ramezani
%A Tabatabaei Yazdi, Farideh
%A Mortazavi, Sayed Ali
%A Abolghasem Danesh
%J Biomass Conversion and Biorefinery
%@ 2190-6815
%D 2022
