Title : ( Modified Sol–Gel Synthesis of Mesoporous Borate Bioactive Glasses for Potential Use in Wound Healing )
Authors: Farzad Kermani , Hossein Sadidi , Ali Ahmadabadi , Seyed Javad Hoseini , Seyed Hasan Tavousi , Alireza Rezapanah , Simin Nazarnezhad , Seyede Atefe Hosseini , Sahar Mollazadeh Beidokhti , Saeid Kargozar ,
Full TextAbstract
In this study, we successfully utilized nitrate precursors for the synthesis of silver (Ag)- doped borate-based mesoporous bioactive glass (MBGs) based on the 1393B3 glass formulation in the presence of a polymeric substrate (polyvinyl alcohol (PVA)) as a stabilizer of boric acid. The X-ray diffraction (XRD) analysis confirmed the glassy state of all the MBGs. The incorporation of 7.5 mol% Ag into the glass composition led to a decrease in the glass transition temperature (Tg). Improvements in the particle size, zeta potential, surface roughness, and surface area values were observed in the Ag-doped MBGs. The MBGs (1 mg/mL) had no adverse effect on the viability of fibroblasts. In addition, Ag-doped MBGs exhibited potent antibacterial activity against gram-positive and gram-negative species. In summary, a modified sol–gel method was confirmed for producing the Ag-doped 1393B3 glasses, and the primary in vitro outcomes hold promise for conducting in vivo studies for managing burns.
Keywords
mesoporous bioactive glass (MBGs); sol–gel synthesis; borate 1393B3 glass; antibacterial activity; tissue engineering
@article{paperid:1091316,
author = {Kermani, Farzad and Hossein Sadidi and Ali Ahmadabadi and Seyed Javad Hoseini and Seyed Hasan Tavousi and Alireza Rezapanah and Simin Nazarnezhad and Seyede Atefe Hosseini and Mollazadeh Beidokhti, Sahar and Saeid Kargozar},
title = {Modified Sol–Gel Synthesis of Mesoporous Borate Bioactive Glasses for Potential Use in Wound Healing},
journal = {Bioengineering},
year = {2022},
volume = {9},
number = {9},
month = {September},
issn = {2306-5354},
pages = {442--460},
numpages = {18},
keywords = {mesoporous bioactive glass (MBGs); sol–gel synthesis; borate 1393B3 glass; antibacterial
activity; tissue engineering},
}
%0 Journal Article
%T Modified Sol–Gel Synthesis of Mesoporous Borate Bioactive Glasses for Potential Use in Wound Healing
%A Kermani, Farzad
%A Hossein Sadidi
%A Ali Ahmadabadi
%A Seyed Javad Hoseini
%A Seyed Hasan Tavousi
%A Alireza Rezapanah
%A Simin Nazarnezhad
%A Seyede Atefe Hosseini
%A Mollazadeh Beidokhti, Sahar
%A Saeid Kargozar
%J Bioengineering
%@ 2306-5354
%D 2022
