6th Iranian Symposium on Brain Mapping Updates , 2022-07-06

Title : ( Altered Effective Connectivity in the Default Mode Network between Healthy Control and Autism Patient Groups: A Resting-State fMRI Study )

Authors: Fateme Mansouri , Fabrice Wallois , Mahdi Saadatmand ,

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Abstract

Autism spectrum disorder (ASD) is a developmental disorder that the certain cause has not been determined yet. The current study examined 154 participants (77 ASD, 77 Controls, between 5 and 9 years) from nine independent datasets of the ABIDE. Previous studies have often examined the functional connectivity, it lacks information about the directed causal influences among the brain regions; however, in the present study, we examined the effective connectivity (EC) of the default mode network (DMN). Effective connectivity is a measurable parameter of brain network connectivity that infers the causality and directionality of connections between a set of regions of interest (ROIs). We used Dynamic Causal Modeling (DCM) to DMN with fully model connected, and used the Parameter Empirical Bayes model (PEB) with considered age, gender, handedness, and IQ of each participant for our group analysis. We found a reduction in effective connectivity default mode network of autistic patients compared to healthy controls. Reduced effective connectivity from mPFC to RIPC, reduced effective connectivity from PCC to mPFC and reduced effective connectivity from PCC to LIPC. We also found decrease self-inhibition in mPFC and RIPC, and an increase in effective connectivity in the male from LIPC to the other regions.

Keywords

Effective connectivity; Autism spectrum disorder; Dynamic Causal Modeling; PEB model; Resting state fMRI; Default Mode Network
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@inproceedings{paperid:1091509,
author = {Mansouri, Fateme and فابریس والوا and Saadatmand, Mahdi},
title = {Altered Effective Connectivity in the Default Mode Network between Healthy Control and Autism Patient Groups: A Resting-State fMRI Study},
booktitle = {6th Iranian Symposium on Brain Mapping Updates},
year = {2022},
location = {تهران, IRAN},
keywords = {Effective connectivity; Autism spectrum disorder; Dynamic Causal Modeling; PEB model; Resting state fMRI; Default Mode Network},
}

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%0 Conference Proceedings
%T Altered Effective Connectivity in the Default Mode Network between Healthy Control and Autism Patient Groups: A Resting-State fMRI Study
%A Mansouri, Fateme
%A فابریس والوا
%A Saadatmand, Mahdi
%J 6th Iranian Symposium on Brain Mapping Updates
%D 2022

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